A 5′ UTR-mediated translational efficiency mechanism inhibits theCandida albicansmorphological transition
نویسندگان
چکیده
منابع مشابه
5′-UTR G-quadruplex structures acting as translational repressors
Given that greater than 90% of the human genome is expressed, it is logical to assume that post-transcriptional regulatory mechanisms must be the primary means of controlling the flow of information from mRNA to protein. This report describes a robust approach that includes in silico, in vitro and in cellulo experiments permitting an in-depth evaluation of the impact of G-quadruplexes as transl...
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Translation of mRNA sequences into proteins typically starts at an AUG triplet. In rare cases, translation may also start at alternative non-AUG codons located in the annotated 5' UTR which leads to an increased regulatory complexity. Since ribosome profiling detects translational start sites at the nucleotide level, the properties of these start sites can then be used for the statistical evalu...
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The regulation of mRNA translation is a major checkpoint in the flux of information from the transcriptome to the proteome. Critical for translational control are the trans-acting factors, RNA-binding proteins (RBPs) and small RNAs that bind to the mRNA and modify its translatability. This review summarizes the mechanisms by which RBPs regulate mRNA translation, with special focus on those bind...
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ژورنال
عنوان ژورنال: Molecular Microbiology
سال: 2014
ISSN: 0950-382X
DOI: 10.1111/mmi.12576